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Irbesartan won't inhibit ACE or renin or affect other hormone receptors or ion channels identified to be involved in the cardiovascular regulation of hypertension and sodium homeostasis.
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Irbesartan: No details can be found in regard to overdosage in individuals. Nevertheless, day by day doses of 900 mg for eight weeks have been nicely tolerated. The probably manifestations of overdosage are predicted to be hypotension and tachycardia; bradycardia might also occur from overdose. Irbesartan is not eradicated by hemodialysis.To obtain up-to-date specifics of the remedy of overdosage, a good resource is actually a Accredited regional Poison Manage Heart. Telephone quantities of Accredited Poison Handle Centers are outlined inside the Physicians’ Desk Reference (PDR).
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Irbesartan's prevention of angiotensin II binding triggers vascular smooth muscle mass leisure and helps prevent the secretion of aldosterone, lowering hypertension.
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